Photo by Joe Fletcher (The St. Regis)
This landmark hotel mixes old-school charm – the bartender remembers your drink and your name – with high-tech amenities. (Rooms have a master panel that controls everything from the lights to the blinds.) For the best views, book one of the Metropolitan Suites.125 3rd St., 415-284-4000
Phoenix Hotel ($)
Parked in the Tenderloin, this mid-century motor inn has grit and style to spare, drawing rock ’n’ rollers like the Killers. Hole up at Chambers eat + drink, the hotel’s new restaurant-lounge that’s done up with a pool, cabanas and a library stocked with 10,000 records.601 Eddy St., 415-776-1380
Air Canada offers daily non-stop service to San Francisco from Vancouver and Toronto.